HISHIPHAGEN-C INJ

HISHIPHAGEN-C INJ (히시파겐씨 주)  is an injectable prescription medication imported from Japan (by Nipro Pharma), marketed by GC Wellbeing (Green Cross) in Korea. It's primarily used as a liver‑function enhancer and an adjuvant therapy for certain allergic skin conditions and drug-related toxicities 

Composition

• Mono‑ammonium glycyrrhizinate (glycyrrhizin derivative): 53 mg per mL (equivalent to ~40 mg glycyrrhizic acid)
• L‑cysteine hydrochloride: 20 mg per mL
• Glycine: 400 mg per mL 

The Pack includes

50 ampules

Benefits

• Liver support: Improves liver enzyme levels in chronic hepatitis and cirrhosis patients, potentially lowering disease progression
• Detoxification: L‑cysteine and glycine aid in metabolizing toxins and drugs 
• Anti‑inflammatory & immune‑modulating: Effective as an adjunct in urticaria, eczema, allergic dermatoses, and drug-induced skin reactions 
• Fatigue and hangover relief: Often known as the “licorice shot,” it’s popularly used for general fatigue and hangover recovery .

Pharmacodynamics

• Mono‑ammonium glycyrrhizinate converts to glycyrrhetinic acid, inhibiting 11β‑hydroxysteroid dehydrogenase type 2, enhancing cortisol activity and producing anti‑inflammatory effects.
• L‑cysteine and glycine serve as antioxidants and support hepatic detoxification 

Dosage & Administration

• Adults: Intravenous injection of 2–20 mL once daily.
• For chronic liver disease: 40–60 mL IV once daily, not to exceed 100 mL/day.
• Adjust according to age, symptoms, and severity. Administered via IV bolus or drip

Duration

• Treatment duration varies based on clinical response and liver enzyme normalization.
• Typically administered once daily over days or weeks, tailored per disease severity and monitoring.